OUP user menu

GENETIC POLYMORPHISMS OF ALCOHOL METABOLIZING ENZYMES RELATED TO ALCOHOL SENSITIVITY AND ALCOHOLIC DISEASES

AKIRA YOSHIDA
DOI: http://dx.doi.org/ 693-696 First published online: 1 November 1994

Abstract

Indiciduals with the atypical aldehyde dehydrogenase ALDH22 allele, both homozygous and heterozygous status, are alcohol sensitive and have a markedly reduced risk of developing alcoholic diseases. Genetic abnormalities of the ALDH1 locus are also associated with alcohol flushing. The ALDH3 and ALDHx, loci are polymorphic and their variations may affect the development of alcoholic diseases. The variations of alcohol dehydrogenase ADH2 and ADH3 loci have no profound effects on alcohol sensitivity. The newly identified ADH6 gene has hormone response elements, and it may cause the gender difference in alcoholic problems.