Alcohol and Alcoholism Advance Access published online on October 17, 2006
Alcohol and Alcoholism, doi:10.1093/alcalc/agl089
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1 Division of Substance Use Disorders, Psychiatric University Clinics, University of Basel, Switzerland
* To whom correspondence should be addressed. Aims: The present study examined the association between pre-treatment drinking and smoking parameters and plasma testosterone levels before and after alcohol withdrawal. Methods: A total of 51 alcohol-dependent men and 43 age-matched healthy men were investigated. In alcoholics, free testosterone in plasma was measured on the day of admission, after detoxification and after 6 weeks of sobriety. Results: While the testosterone level of alcoholic men did not differ from healthy controls at the onset of withdrawal, it was significantly higher for the alcoholics after 6 weeks of sobriety than for the healthy controls. Higher alcohol consumption and higher tobacco use before detoxification led to higher levels of testosterone concentration before and after withdrawal. Conclusions: The effect of alcohol and tobacco is cumulative, with higher levels of alcohol and tobacco consumption being associated with higher levels of testosterone before and after alcohol withdrawal.
Received July 7, 2006
Revised August 17, 2006
Accepted September 12, 2006
Article
CONTROLLED STUDY ON THE COMBINED EFFECT OF ALCOHOL AND TOBACCO SMOKING ON TESTOSTERONE IN ALCOHOL-DEPENDENT MEN
MARC WALTER 1 *, URS GERHARD 1, MANFRED GERLACH 2, HEINZ-GERD WEIJERS 3, JOBST BOENING 4, and GERHARD A. WIESBECK 1
2 Department of Child and Adolescent Psychiatry, University of Würzburg, Germany
3 University of Applied Police Sciences Aschersleben, Germany
4 Clinical Addiction Medicine, Psychiatric University Hospital Würzburg, Germany
MARC WALTER, E-mail: marc.walter{at}upkbs.ch
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