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Alcohol and Alcoholism Advance Access published online on October 18, 2006
Alcohol and Alcoholism, doi:10.1093/alcalc/agl087
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© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved
Received August 28, 2006
Revised August 28, 2006
Accepted September 5, 2006

Article

AVERAGE VOLUME OF ALCOHOL CONSUMED, TYPE OF BEVERAGE, DRINKING PATTERN AND THE RISK OF DEATH FROM ALL CAUSES

LAURA BAGLIETTO 1, DALLAS R. ENGLISH 1, JOHN L. HOPPER 2, JOHN POWLES 3, and GRAHAM G. GILES 1 *

1 Cancer Epidemiology Centre, The Cancer Council of Victoria, Melbourne, Australia; Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, The University of Melbourne, Melbourne, Australia
2 Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, The University of Melbourne, Melbourne, Australia
3 Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK

* To whom correspondence should be addressed.
GRAHAM G. GILES, E-mail: graham.giles{at}cancervic.org.au


  Abstract

Background: The objective was to investigate associations between average volume of alcohol consumption, type of beverage and drinking pattern and all-cause mortality in the Melbourne Collaborative Cohort Study. Methods: Average consumption, including type of beverage, was estimated from beverage-specific questions on quantity and frequency of consumption. Pattern of consumption was estimated from a 7-day diary. During an average of 10.5 years of follow-up of 36 984 participants, 1971 deaths occurred. Results: For both men and women, mortality curves were J-shaped (nadir at 9-12 g/day of alcohol consumption; upper protective dose of 42-76 g/day). Wine consumption was associated with lower mortality (for men, minimum hazard ratio (HR) at 20-39 g/day of wine consumption: 0.69; 95% confidence interval (CI): 0.54-0.87; for women, minimum HR at 1-19 g/day: 0.82; 95% CI: 0.70-0.98). Beer was associated with an increased risk for men (test for trend, P = 0.05), but not for women. After adjustment for total amount of alcohol consumed, the number of drinking-days was inversely associated with the risk of dying in men (P-trend = 0.04). Conclusions: These results confirm previous findings about the effect of average volume of alcohol and type of beverage and suggest that drinking pattern is an independent risk factor for all-cause mortality.


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