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Alcohol and Alcoholism Advance Access published online on May 9, 2006
Alcohol and Alcoholism, doi:10.1093/alcalc/agl037
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© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved
Received November 7, 2005
Revised February 6, 2006
Accepted March 31, 2006

Article

EFFECTS OF ARIPIPRAZOLE ON ALCOHOL INTAKE IN AN ANIMAL MODEL OF HIGH-ALCOHOL DRINKING

KIMMO INGMAN 1 *, JOHANNA KUPILA 1, PETRI HYYTIÄ 2, and ESA R. KORPI 3

1 Department of Pharmacology and Clinical Pharmacology, University of Turku, FI-20520 Turku, Finland
2 Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
3 The Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland

* To whom correspondence should be addressed.
KIMMO INGMAN, E-mail: kiming{at}utu.fi


  Abstract

Aims: This study examined the effects of aripiprazole, a novel atypical antipsychotic drug with partial agonist properties at dopamine D2 receptors, on the voluntary limited access alcohol drinking of alcohol-preferring AA (Alko, Alcohol) rats. Methods: AA rats were taught to drink 10% alcohol in a 4 h limited access paradigm. Effects of acute aripiprazole (0, 0.3, 1.0, and 3.0 mg/kg) on the limited access alcohol drinking were studied. In repeated treatment experiment, aripiprazole (0, 1.0, and 6.0 mg/kg) was administered once daily over five successive days. To reveal any effect by aripiprazole not selective for alcohol drinking, 0.025% saccharin solution was substituted for alcohol during the 4 h limited access, and acute treatments were repeated. The effects of aripiprazole on ambulatory locomotor activity were tested with doses that were used in the acute experiments. Results: Acute aripiprazole at the doses of 0.3, 1.0, and 3.0 mg/kg had no effect on alcohol drinking. Repeated treatment with the aripiprazole dose of 6.0 mg/kg significantly diminished alcohol drinking at the 1 h time point. This dose had no effect on saccharin drinking when given acutely. Acute aripiprazole at the doses of 1.0, 3.0, and 6.0 mg/kg significantly suppressed locomotor activity. Conclusions: Aripiprazole decreased limited access alcohol drinking in AA rats, but only at a high dose that also strongly suppressed locomotor activity.


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