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Alcohol and Alcoholism Advance Access published online on April 19, 2006
Alcohol and Alcoholism, doi:10.1093/alcalc/agl028
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© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved
Received October 17, 2005
Revised March 21, 2005
Accepted March 22, 2006

Article

ALDH2 PROMOTER POLYMORPHISM HAS NO EFFECT ON THE RISK FOR ALCOHOLISM

MITSURU KIMURA 1, SHIGEKO KIMURA 1, SACHIO MATSUSHITA 1, HARUO KASHIMA 2, and SUSUMU HIGUCHI 1 *

1 National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
2 Department of Neuropsychiatry, School of Medicine, Keio University, Shinjuku, Tokyo, Japan

* To whom correspondence should be addressed.
SUSUMU HIGUCHI, E-mail: shiguchi{at}wa2.so-net.ne.jp


  Abstract

Aim: To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism. Methods: Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed. Results: There were no significant differences between the genotype and allele frequencies of the -357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms. Conclusion: These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.


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