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Alcohol and Alcoholism Advance Access published online on March 22, 2006
Alcohol and Alcoholism, doi:10.1093/alcalc/agl013
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© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved
Received October 24, 2005
Revised February 2, 2006
Accepted February 3, 2006

Article

ROSIGLITAZONE RELIEVES ACUTE ETHANOL-INDUCED HANGOVER IN SPRAGUE-DAWLEY RATS

TAE WOO JUNG 1, JI YOUNG LEE 1, WAN SUB SHIM 2, EUN SEOK KANG 2, SOO KYUNG KIM 3, CHUL WOO AHN 4, HYUN CHUL LEE 4, and BONG SOO CHA 4 *

1 The Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
3 The Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea; Department of Internal Medicine, Pochon CHA University College of Medicine, Sungnam, Korea
4 The Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

* To whom correspondence should be addressed.
BONG SOO CHA, E-mail: bscha{at}yumc.yonsei.ac.kr


  Abstract

Aims: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. Methods: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis. Results: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. Conclusions: Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.


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