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Alcohol and Alcoholism Advance Access published online on December 13, 2005

Alcohol and Alcoholism, doi:10.1093/alcalc/agh252
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© The Author 2005. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved
Received September 29, 2005
Revised November 9, 2005
Accepted November 10, 2005


Article

COMORBID PHOBIC DISORDERS DO NOT INFLUENCE OUTCOME OF ALCOHOL DEPENDENCE TREATMENT. RESULTS OF A NATURALISTIC FOLLOW-UP STUDY

LOES A. MARQUENIE 1 *, ANNEMIEK SCHADÉ 1, ANTON J. L. M. VAN BALKOM 1, MAARTEN KOETER 2, SIPKE FRENKEN 1, WIM VAN DEN BRINK 2, and RICHARD VAN DYCK 1

1 Department of Psychiatry and Institute for Research in Extramural Medicine, VU--University Medical Centre, GGZ Buitenamstel, Amsterdam, The Netherlands
2 Academic Medical Centre, University of Amsterdam, Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands

* To whom correspondence should be addressed.
LOES A. MARQUENIE, E-mail: LMarquenie{at}ggzba.nl


   Abstract

Aims: Despite claims that comorbid anxiety disorders tend to lead to a poor outcome in the treatment of alcohol dependence, the few studies on this topic show conflicting results. Objective: To test whether the outcome of treatment-seeking alcohol-dependent patients with a comorbid phobic disorder is worse than that of similar patients without a comorbid phobic disorder. Methods: The probabilities of starting to drink again and of relapsing into regular heavy drinking in (i) a group of 81 alcohol-dependent patients with comorbid social phobia or agoraphobia were compared with those in (ii) a group of 88 alcohol-dependent patients without anxiety disorders in a naturalistic follow-up using Cox regression analysis. Results: Adjusted for initial group differences, the hazard ratio for the association of phobic disorders with resumption of drinking was 1.05 (95% CI, 0.85-1.30, P = 0.66) and the adjusted hazard ratio for the association of phobic disorders with a relapse into regular heavy drinking was 1.02 (95% CI, 0.78-1.33, P = 0.89). Conclusion: The findings of this study do not confirm the idea that alcohol-dependent patients who have undergone alcohol-dependence treatment are at greater risk of a relapse if they have a comorbid anxiety disorder. No differences were found in abstinence duration or time to relapse into regular heavy drinking between patients with and without comorbid phobic disorders.


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