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Alcohol and Alcoholism Advance Access published online on October 20, 2005
Alcohol and Alcoholism, doi:10.1093/alcalc/agh225
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© The Author 2005. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved
Received July 14, 2005
Accepted September 29, 2005

Article

GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS

HALINA CICHOZ-LACH 1*, JADWIGA PARTYCKA 1, IRINA NESINA 2, KRZYSZTOF CELINSKI 1, MARIA SLOMKA 1, and JACEK WOJCIEROWSKI 2

1 Department of Gastroenterology, Medical University of Lublin, ul. Jaczewskiego 8, Lublin, Poland
2 Department of Medical Genetics, Medical University of Lublin, ul. Jaczewskiego 8, Lublin, Poland

* To whom correspondence should be addressed.
HALINA CICHOZ-LACH, E-mail: Lach.Halina{at}wp.pl


  Abstract

Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR-restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in alcohol abusers compared with non-drinkers. The examinations of the group of alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of alcohol dependence between genders in the Polish population.


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