Alcohol and Alcoholism Advance Access published online on March 29, 2005
Alcohol and Alcoholism, doi:10.1093/alcalc/agh154
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division on Substance Abuse, NYS Psychiatric Institute and Columbia University, Unit/120, 1051 Riverside Drive, New York, NY, USA
* To whom correspondence should be addressed. Aims: To examine the effects of an acute dose of ethanol on serum fatty acid ethyl esters (FAEEs) concentration and urinary 5-hydroxytryptophol (5-HTOL)/5-hydroxyindole-3-acetic acid (5-HIAA) ratio. Methods: Sixteen (14 male, 2 female) heavy alcohol drinkers were tested in a single, 2-day long session. Six participants received 1.5 g/l of ethanol/l of body water (
Received November 12, 2004
Revised January 26, 2005
Accepted March 9, 2005
Article
COMPARISON OF SERUM FATTY ACID ETHYL ESTERS AND URINARY 5-HYDROXYTRYPTOPHOL AS BIOCHEMICAL MARKERS OF RECENT ETHANOL CONSUMPTION
2 Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
3 Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
ADAM BISAGA, E-mail: amb107{at}columbia.edu
Abstract 
0.75 g/kg of body weight, low dose group: LD) and 10 participants received 2.0 g/l of ethanol (1.0 g/kg of body weight, high dose group: HD) in four divided doses every 20 min. Blood, urine, and breath samples were collected repeatedly over 36 h following the ingestion of ethanol and were analyzed for the presence of FAEE, 5-HTOL/5-HIAA, and ethanol, respectively. Serum 
-glutamyltransferase (GGT), a marker of chronic ethanol use, was also included. Results: The breath ethanol level peaked 1 h after the last dose, at 95 and 120 mg/dl for the LD and HD groups, respectively. The mean ratio of urinary 5-HTOL/5-HIAA was significantly elevated 5 and 9 h after ethanol administration, but returned to baseline 13 h after ethanol administration. This ratio was twice as high for the HD group compared with the LD group. Serum levels of FAEEs were significantly elevated at 5 h, but not 13 h after ethanol administration. There were no time-dependent changes in serum GGT levels. Conclusions: Measuring the levels of FAEE and 5-HTOL/5-HIAA ratio provides a convenient method to detect recent, particularly binge-type, ethanol use, but these measures may have limited applicability in detecting ethanol use in traditional clinical trial settings.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Kravos and I. Malesic Glutamate Dehydrogenase as a Marker of Alcohol Dependence Alcohol Alcohol., October 7, 2009; (2009) agp070v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. O. SALEM, M. LAPOSATA, R. RAJENDRAM, J. E. CLUETTE-BROWN, and V. R. PREEDY THE TOTAL BODY MASS OF FATTY ACID ETHYL ESTERS IN SKELETAL MUSCLES FOLLOWING ETHANOL EXPOSURE GREATLY EXCEEDS THAT FOUND IN THE LIVER AND THE HEART Alcohol Alcohol., November 1, 2006; 41(6): 598 - 603. [Abstract] [Full Text] [PDF]
|
|