Skip Navigation



Alcohol and Alcoholism Advance Access published online on March 29, 2005
Alcohol and Alcoholism, doi:10.1093/alcalc/agh153
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
40/3/181    most recent
agh153v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PASTOR, I. J.
Right arrow Articles by GONZÁLEZ-SARMIENTO, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PASTOR, I. J.
Right arrow Articles by GONZÁLEZ-SARMIENTO, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Alcohol & Alcoholism © Medical Council on Alcohol 2005; all rights reserved
Received November 25, 2004
Revised February 23, 2005
Accepted March 8, 2005

Article

INTERLEUKIN-1 GENE CLUSTER POLYMORPHISMS AND ALCOHOLISM IN SPANISH MEN

ISABEL J. PASTOR 1, FRANCISCO JAVIER LASO 2, ALFONSO ROMERO 3, and ROGELIO GONZÁLEZ-SARMIENTO 4*

1 Unidad de Medicina Molecular, Departamento de Medicina, Hospital Universitario de Salamanca, Salamanca, Spain; Unidad de Alcoholismo. Servicio de Medicina Interna, Hospital Universitario de Salamanca, Salamanca, Spain; Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Salamanca, Salamanca, Spain
2 Unidad de Medicina Molecular, Departamento de Medicina, Hospital Universitario de Salamanca, Salamanca, Spain; Unidad de Alcoholismo. Servicio de Medicina Interna, Hospital Universitario de Salamanca, Salamanca, Spain
3 Unidad de Alcoholismo. Servicio de Medicina Interna, Hospital Universitario de Salamanca, Salamanca, Spain
4 Unidad de Medicina Molecular, Departamento de Medicina, Hospital Universitario de Salamanca, Salamanca, Spain; Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Salamanca, Salamanca, Spain

* To whom correspondence should be addressed.
ROGELIO GONZÁLEZ-SARMIENTO, E-mail: Gonzalez{at}usal.es


  Abstract

Aims: In an attempt to explain differences in susceptibility to alcoholism and alcohol liver disease (ALD), different genes have been analysed, among them those encoding inflammatory cytokines. Thus, it has been reported recently that both the interleukin 1 receptor antagonist (IL1RN) and the IL1{beta} (IL1B) genes may influence the risk of ALD in Japanese alcoholics. We analysed the distribution of single nucleotide polymorphisms (SNPs) located in the IL1A, IL1B, IL1R1 and IL1RN genes in alcoholic and non-alcoholic Spanish subjects. Methods: DNA samples were obtained from 139 male alcoholics, 78 of whom were diagnosed as alcohol dependent (32 patients with liver cirrhosis and 46 without ALD) and 61 as alcohol abusers (25 with liver cirrhosis and 36 without ALD). As a control, we studied 81 age- and sex-matched healthy volunteers. Results: Alleles -511 IL1B*1 and IL1RN*1 were represented more in alcoholic patients than in the control group. We did not find any association of alcoholism or ALD with polymorphisms in the IL1A and IL1R1 genes. Conclusions: We conclude that the proteins encoded by the IL1RN and IL1B genes may be involved in susceptibility to alcoholism in Spanish men, probably through a different pathway from that involved in the regulation of the inflammatory response.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
M. Marcos, I. Pastor, R. GonzAlez-Sarmiento, and F. J. Laso
Interleukin-10 Gene Polymorphism is Associated with Alcoholism but not With Alcoholic Liver Disease
Alcohol Alcohol., September 1, 2008; 43(5): 523 - 528.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.