Skip Navigation


Alcohol and Alcoholism Advance Access first published online on January 24, 2005
This version published online on February 17, 2005
Alcohol and Alcoholism, doi:10.1093/alcalc/agh134
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
40/3/194    most recent
agh134v2
agh134v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by CALDWELL, L. C.
Right arrow Articles by TAPERT, S. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CALDWELL, L. C.
Right arrow Articles by TAPERT, S. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Alcohol & Alcoholism © Medical Council on Alcohol 2005; all rights reserved
Received October 18, 2004
Revised November 24, 2004
Accepted December 7, 2004

Article

GENDER AND ADOLESCENT ALCOHOL USE DISORDERS ON BOLD (BLOOD OXYGEN LEVEL DEPENDENT) RESPONSE TO SPATIAL WORKING MEMORY

LISA C. CALDWELL 1, ALECIA D. SCHWEINSBURG 2, BONNIE J. NAGEL 3, VALERIE C. BARLETT 1, SANDRA A. BROWN 4, and SUSAN F. TAPERT 5*

1 Veterans Medical Research Foundation, University of California, San Diego, USA
2 Department of Psychology, University of California, San Diego, USA
3 Veterans Medical Research Foundation, University of California, San Diego, USA; Department of Psychiatry, University of California, San Diego, USA
4 Department of Psychology, University of California, San Diego, USA; Department of Psychiatry, University of California, San Diego, USA; VA San Diego Healthcare System, CA, USA
5 Veterans Medical Research Foundation, University of California, San Diego, USA; Department of Psychology, University of California, San Diego, USA; Department of Psychiatry, University of California, San Diego, USA; VA San Diego Healthcare System, CA, USA

* To whom correspondence should be addressed.
SUSAN F. TAPERT, E-mail: stapert{at}ucsd.edu


  Abstract

Aims: To determine how alcohol use differentially affects brain functioning in male and female adolescents. Methods: Adolescents with alcohol use disorders (AUDs; 7 female, 11 male) and control adolescents without AUDs (9 female, 12 male), aged 14-17 years, performed spatial working memory and vigilance tasks during functional magnetic resonance imaging. Results: Gender, AUD and their interaction were significantly associated with brain activation patterns to the tasks. There were interactions in the superior frontal, superior temporal, cingulate and fusiform regions, in which female and male adolescents with AUDs showed a different brain response from each other and control subjects. Overall, female adolescents with AUDs showed a greater departure from normal activation patterns than male adolescents with AUD. Conclusions: Adolescent alcohol involvement may affect male and female brains differently, and adolescent females may be somewhat more vulnerable to adverse alcohol effects. With continued drinking, these adolescents may be at an increased risk for behavioural deficits.

The title of this paper has been amended to give more detail
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Child Health CareHome page
T. Vallido, D. Jackson, and L. O'Brien
Mad, sad and hormonal: the gendered nature of adolescent sleep disturbance
J Child Health Care, March 1, 2009; 13(1): 7 - 18.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.