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Alcohol and Alcoholism Advance Access published online on January 24, 2005
Alcohol and Alcoholism, doi:10.1093/alcalc/agh134
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Alcohol & Alcoholism © Medical Council on Alcohol 2005; all rights reserved
Received October 18, 2004
Revised November 24, 2004
Accepted December 7, 2004

Article

GENDER AND ADOLESCENT ALCOHOL USE DISORDERS ON BOLD RESPONSE TO SPATIAL WORKING MEMORY

LISA C. CALDWELL 1, ALECIA D. SCHWEINSBURG 2, BONNIE J. NAGEL 3, VALERIE C. BARLETT 1, SANDRA A. BROWN 4, and SUSAN F. TAPERT 5*

1 Veterans Medical Research Foundation, University of California, San Diego, USA
2 Department of Psychology, University of California, San Diego, USA
3 Veterans Medical Research Foundation, University of California, San Diego, USA; Department of Psychiatry, University of California, San Diego, USA
4 Department of Psychology, University of California, San Diego, USA; Department of Psychiatry, University of California, San Diego, USA; VA San Diego Healthcare System, CA, USA
5 Veterans Medical Research Foundation, University of California, San Diego, USA; Department of Psychology, University of California, San Diego, USA; Department of Psychiatry, University of California, San Diego, USA; VA San Diego Healthcare System, CA, USA

* To whom correspondence should be addressed.
SUSAN F. TAPERT, E-mail: stapert{at}ucsd.edu


  Abstract

Aims: To determine how alcohol use differentially affects brain functioning in male and female adolescents. Methods: Adolescents with alcohol use disorders (AUDs; 7 female, 11 male) and control adolescents without AUDs (9 female, 12 male), aged 14-17 years, performed spatial working memory and vigilance tasks during functional magnetic resonance imaging. Results: Gender, AUD and their interaction were significantly associated with brain activation patterns to the tasks. There were interactions in the superior frontal, superior temporal, cingulate and fusiform regions, in which female and male adolescents with AUDs showed a different brain response from each other and control subjects. Overall, female adolescents with AUDs showed a greater departure from normal activation patterns than male adolescents with AUD. Conclusions: Adolescent alcohol involvement may affect male and female brains differently, and adolescent females may be somewhat more vulnerable to adverse alcohol effects. With continued drinking, these adolescents may be at an increased risk for behavioural deficits.


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