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Alcohol and Alcoholism Advance Access published online on November 1, 2004
Alcohol and Alcoholism, doi:10.1093/alcalc/agh108
© 2004 by Medical Council on Alcohol
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Received June 3, 2004
Revised September 9, 2004
Accepted October 11, 2004

Article

INCREASED FASTING PLASMA GHRELIN LEVELS DURING ALCOHOL ABSTINENCE

DAI-JIN KIM 1, SU-JUNG YOON 2*, BOMOON CHOI 1, TAE-SUK KIM 1, YOUNG SUP WOO 1, WON KIM 1, HUGH MYRICK 3, BRADLEY S. PETERSON 4, YOUNG BIN CHOI 5, YONG-KU KIM 6, and JAESEUNG JEONG 7

1 Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea
2 Department of Psychiatry, KARF Hospital, South Korea
3 Department of Psychiatry, Medical University of South Carolina, USA
4 Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, USA
5 Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea
6 Department of Psychiatry, Korea University Ansan Hospital, South Korea
7 Department of BioSystems, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

* To whom correspondence should be addressed.
SU-JUNG YOON, E-mail: kdj922{at}chollian.net


  Abstract

Aims: Ghrelin is a peptide hormone that antagonizes the action of leptin and is thereby thought to regulate feeding behaviour. The actions of ghrelin and leptin appear to be mediated by the neuropeptide Y (NPY) and Agouti-related protein (AGRP) system. Recent studies have suggested that leptin and NPY play significant roles in the pathophysiology of alcoholism. The aim of this study was to determine whether ghrelin is associated with the state and duration of abstinence in individuals with alcohol dependence. Methods: Fasting plasma ghrelin levels were compared between 47 individuals with chronic alcoholism during a period of abstinence and 50 control subjects. Results: Fasting plasma ghrelin levels were higher in alcohol abstainers than those in controls. Furthermore, a positive correlation was observed between ghrelin levels and the duration of abstinence. In addition, daily alcohol intake prior to abstinence was inversely related to ghrelin levels. Conclusions: These findings suggest that ghrelin plays a role in the pathogenesis of alcohol dependence, particularly during the abstinence period, in individuals with chronic alcoholism.


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