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Alcohol and Alcoholism Advance Access published online on October 21, 2004
Alcohol and Alcoholism, doi:10.1093/alcalc/agh096
© 2004 by Medical Council on Alcohol
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Received April 5, 2004
Revised August 27, 2004
Accepted August 28, 2004

Article

DIMINISHED CD4+ T CELL SURFACE CCR5 EXPRESSION IN ALCOHOLIC PATIENTS

PASCAL PERNEY 1*, PIERRE PORTALÈS 2, JACQUES CLOT 2, FRANÇOIS BLANC 3, and PIERRE CORBEAU 2

1 Service de Médecine Interne E, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France; Laboratoire d'Immunologie, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France
2 Laboratoire d'Immunologie, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France
3 Service de Médecine Interne E, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France

* To whom correspondence should be addressed.
PASCAL PERNEY, E-mail: p-perney{at}chu-montpellier.fr


  Abstract

Aims: The C-C chemokine receptors, particularly the CCR5, appeared to play an important role in T cell-mediated inflammatory reactions. The aim of our study was to assess the impact of chronic alcohol consumption on the in vivo CCR5 expression. Methods: Fourteen alcoholic men hospitalized for a detoxification programme were prospectively included and compared with 49 agematched controls. Results: The CD4+ T cell surface CCR5 densities were drastically lower in alcoholic patients [mean, 5319 molecules/cell; 95% confidence interval (CI) 4477-6162] as compared with CCR5 densities of the controls (10 944 molecules/cell [CI 9929-11959]; P < 10-4). Conclusions: Chronic alcohol consumption is associated with a significant decrease of CCR5 expression, which could favour Th1/Th2 imbalance.


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