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Alcohol and Alcoholism Advance Access first published online on September 6, 2004
This version published online on September 17, 2004
Alcohol and Alcoholism, doi:10.1093/alcalc/agh089
© 2004 by Medical Council on Alcohol
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Received March 18, 2004
Revised July 12, 2004
Accepted July 17, 2004

Article

A PILOT STUDY OF ALCOHOL EXPOSURE AND PHARMACOKINETICS IN WOMEN WITH OR WITHOUT CHILDREN WITH FETAL ALCOHOL SYNDROME

NATHANIEL C. O. KHAOLE 1*, VIJAY A. RAMCHANDANI 2, DENIS L. VILJOEN 3, and TING-KAI LI 2

1 Foundation for Alcohol Related Research, University of Cape Town Medical School, Cape Town, South Africa
2 Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
3 Foundation for Alcohol Related Research, Department of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand and South African Institute of Medical Research, Johannesburg, South Africa

* To whom correspondence should be addressed. E-mail: nat.khaole{at}mweb.co.za.


  Abstract

Aims: To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children. Methods: 10 women who had given birth to FAS children (FAS mothers) and 20 Controls were studied to determine how they metabolize alcohol in a single limited-access quasi-experimental session of voluntary consumption of alcohol. They had free choice in the consumption of any amount of their favourite beverage for ~2.5 h, but their drinking was terminated if the breath alcohol concentrations (BrAC) exceeded 150 mg%. BrACs was measured during ethanol consumption and for several hours after, for estimation of alcohol exposure and pharmacokinetics. Results: FAS mothers consumed significantly larger amounts of alcohol, and achieved significantly higher peak BrAC levels than Controls. The rate of decline of alcohol from the circulation ({beta}-60) showed a 2-fold variation across subjects but there was no significant difference between the two groups. Conclusions: This study did not show any difference in alcohol pharmacokinetics in free-choice drinking by non-pregnant women, who either have given or have never given birth to FAS children. However, mothers of FAS children tend to consume more alcohol per session. Future studies in larger samples will be needed to confirm these findings and to examine drinking patterns and other factors that may increase the risk of FAS in children of women who drink alcohol during pregnancy.


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