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Alcohol and Alcoholism Advance Access published online on August 10, 2004
Alcohol and Alcoholism, doi:10.1093/alcalc/agh086
© 2004 by Medical Council on Alcohol
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Received May 24, 2004
Revised June 24, 2004
Accepted June 29, 2004

Article

ANALYSIS OF 5-HYDROXYTRYPTAMINE 2C RECEPTOR GENE PROMOTER VARIANTS AS ALCOHOL-DEPENDENCE RISK FACTORS

SALIM MOTTAGUI-TABAR 1, SHANE MCCARTHY 1, JANA REINEMUND 1, BJÖRN ANDERSSON 1, CLAES WAHLESTEDT 1, MARKUS HEILIG 2*

1 Center for Genomics and Bioinformatics, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
2 Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden

* To whom correspondence should be addressed. E-mail: markus.heilig{at}neurotec.ki.se.


  Abstract

Aims: To examine whether polymorphic variants of the HTR2C gene are associated with diagnosis of alcohol dependence. Methods: We compared allele frequencies of five HTR2C promoter polymorphisms in a Nordic population of alcohol dependent individuals (Males: n = 309; Females: n = 127) and ethnically matched controls (Males: n = 83; Females: n = 190) in whom alcohol dependence was established, or any diagnosis of substance disorder was excluded, respectively. Patients were further subtyped into Type I (late onset) and Type II (early onset) alcoholics. Results: None of the individual polymorphisms indicated significant association with alcohol dependence. A common promoter haplotype (GAGG) exhibited different distribution frequencies between males and females (Type I), however on Bonferroni's multiple-testing correction, this observation proved to be insignificant. Conclusions: Although we report a lack of association between alcohol dependence and five common promoter polymorphisms, and the constituted haplotypes, the analysis tends to indicate gender and sub-type differences. We suggest that a follow up study with larger sample numbers should be performed to improve the power to detect the genetic influences of HTR2C in alcohol dependence.


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