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Alcohol and Alcoholism Advance Access published online on August 2, 2004
Alcohol and Alcoholism, doi:10.1093/alcalc/agh076
© 2004 by Medical Council on Alcohol
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Received October 23, 2003
Revised May 10, 2004
Accepted May 12, 2004

Article

HIGH ALCOHOL PREFERRING (HAP) AND LOW ALCOHOL PREFERRING (LAP) RATS SHOW ALTERED PROOPIOMELANOCORTIN (POMC) MESSENGER RNA EXPRESSION IN THE ARCUATE NUCLEUS

HIROSHI KINOSHITA 1*, MICHAEL S. HARBUZ 2, MINORI NISHIGUCHI 1, HARUMI OUCHI 1, TAKAKO MINAMI 1, TAKAO UTSUMI 3, HIROYUKI MOTOMURA 4, SHIGERU HISHIDA 1

1 Department of Legal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan
2 LINE, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
3 Department of Ophthalmology, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan
4 Forensic Science Laboratory, Hyogo Prefectural Police Headquarters, 4-1, Shimoyamate-dori 5-chome, Chuo-ku, Kobe, 650-8510, Japan

* To whom correspondence should be addressed. E-mail: kinochin{at}hyo-med.ac.jp.


  Abstract

Aims and Methods: We have investigated proopiomelanocortin (POMC) and neuropeptide Y (NPY) gene expression in the arcuate nucleus of the hypothalamus comparing high alcohol preference (HAP) rats and low alcohol preference (LAP) rats under basal conditions using in situ hybridization histochemistry. Results: A significantly higher expression of POMC mRNA was observed in HAP rats compared with LAP rats. In contrast, no difference in NPY mRNA expression was observed between the two rat lines. Conclusions: These data suggest that an endogenous opioid system may contribute to alcohol preference in HAP/LAP rat lines.


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