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Alcohol and Alcoholism Advance Access originally published online on December 15, 2006
Alcohol and Alcoholism 2007 42(2):158-160; doi:10.1093/alcalc/agl091
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© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved

CASE REPORT

SUPPRESSION OF SYMPTOMS OF ALCOHOL DEPENDENCE AND CRAVING USING HIGH-DOSE BACLOFEN

WILLIAM BUCKNAM*

No. 207, 5340 Plymouth Road Ann Arbor, MI 48105, USA

*E-mail: wbucknam{at}hotmail.com

Received 14 July 2006; in revised form 8 August 2006; in revised form 18 August 2006; accepted 5 September 2006


  Abstract

Aims: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. Methods: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. Results: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. Conclusions: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.


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