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Alcohol & Alcoholism Vol. 39, No. 1, pp. 14-19, 2004
© Medical Council on Alcohol 2004; all rights reserved

EFFECT OF NALTREXONE ADMINISTRATION ON SHORT-TERM MEMORY IN CHRONICALLY ETHANOL-TREATED OUTBRED RATS

I. Okulicz-Kozaryn, P. Mikolajczak*, E. Kaminska, I. Kaminska, M. Szulc and T. Bobkiewicz-Kozlowska

Department of Pharmacology, University of Medical Sciences, Poznan, Poland

* Author to whom correspondence should be addressed at: Department of Pharmacology, University of Medical Sciences in Poznan, Rokietnicka 5a, 60–806 Poznan, Poland. Tel.: +4861 8694394; Fax: +4861 8694481.

(Received 13 May 2003; first review notified 11 June 2003; in revised form 18 September 2003; accepted 2 October 2003)

Aims: The purpose of this study was to evaluate the effect of naltrexone treatment for 21 consecutive days on short-term memory in ethanol-preferring and non-preferring outbred rats. Methods: Ethanol preferring, non-preferring and control Wistar rats were treated with naltrexone [0.1 mg/kg intraperitoneally (i.p.)] for 21 consecutive days. Short-term memory was assessed by using an olfactory social recognition test. Results: A single administration of naltrexone (0.1 mg/kg i.p.) to non-ethanol-treated animals facilitated social memory, whereas the drug did not affect short-term memory in either group of chronically ethanol-treated rats. Multiple naltrexone treatment also lowered alcohol intake in ethanol-preferring rats. Conclusion: Naltrexone–ethanol interaction does not seem to produce any negative effect on the short-term memory in outbred rats.


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