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Alcohol and Alcoholism Vol. 38, No. 4, pp. 386-389, 2003
© 2003 Medical Council on Alcohol

RAPID COMMUNICATION

ALCOHOL INTAKE AFTER SEROTONIN TRANSPORTER INACTIVATION IN MICE

Sabah Kelaï, Franck Aïssi1, Klaus Peter Lesch2, Charles Cohen-Salmon1, Michel Hamon and Laurence Lanfumey*

INSERM U288, Neuropsychopharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l’Hôpital, 75634 Paris Cedex 13,
1 CNRS UMR-7593, Personnalité et conduites adaptatives, IFR (70) des Neurosciences, CHU Pitié-Salpêtrière, 75013 Paris, France and
2 Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany

Received 28 February 2003; first review notified 3 April 2003; accepted 3 April 2003

Knock-out mice lacking the serotonin transporter [5-hydroxytryptamine transporter (5-HTT)] were used to assess the influence of 5-HT re-uptake on ethanol consumption. Under a free-choice paradigm, alcohol intake was lower in mutant than in wild-type mice, and pharmacological blockade of 5-HTT by fluoxetine reduced alcohol intake in wild-type mice only. These data confirm the inhibitory effect of 5-HTT inactivation on ethanol intake.


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