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Alcohol and Alcoholism Vol. 38, No. 3, pp. 270-275, 2003
© 2003 Medical Council on Alcohol

MULTICENTRE EVALUATION OF A NEW ASSAY FOR DETERMINATION OF CARBOHYDRATE-DEFICIENT TRANSFERRIN

Markus J. Schwarz, Ingrid Domke2, Anders Helander3, Pim M. W. Janssens4, Johannes van Pelt5, Beate Springer1, Manfred Ackenheil, Klaus Bernhardt1, Gerhard Weigl1 and Michael Soyka*

Psychiatrische Klinik der Ludwig-Maximilian-Universität, München, Germany,
1 Zentrallabor, Otto-Wagner-Spital, Wien, Austria,
2 Roche Diagnostics GmbH, Mannheim, Germany,
3 Department of Clinical Neuroscience and Clinical Chemistry, Karolinska Institute, Stockholm, Sweden,
4 Department of Clinical Chemistry, Ziekenhuis Rijnstate, Arnhem and
5 Department of Clinical Chemistry, Ziekenhuizen Noord-Limburg, Venlo, The Netherlands

Received 30 July 2002; first review notified 12 December 2002; accepted 6 January 2003

Aims: The analytical performance of the new Tina-quant % carbohydrate-deficient transferrin (%CDT) was assessed in a multicentre study on Roche/Hitachi analysers. Methods: Intra-assay/total precision studies revealed median coefficients of variation (CVs) of 4.7/7.4% within the sites. Precision between the sites was proven using a serum panel. Results: Inter-laboratory CVs from 6.3 to 10.7% were obtained. The results of the participating laboratories compared well with high-performance liquid chromatography-UV technique fulfilling the criteria of a reference method for %CDT determination (slope 1.03, intercept -0.09% CDT, correlation 0.984). Good agreement was also found with the Axis-Shield %CDT microtitre test. Conclusions: Data from this study indicate that reliable, well standardized %CDT results are obtained using the new assay.


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