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Alcohol and Alcoholism Vol. 38, No. 2, pp. 168-175, 2003
© 2003 Medical Council on Alcohol

ALCOHOL WITHDRAWAL TREATMENT IN INTOXICATED VS NON-INTOXICATED PATIENTS: A CONTROLLED OPEN-LABEL STUDY WITH TIAPRIDE/CARBAMAZEPINE, CLOMETHIAZOLE AND DIAZEPAM

M. Lucht*, K. U. Kuehn, J. Armbruster, G. Abraham, M. Gaensicke, S. Barnow, H. Tretzel and H. J. Freyberger

Department of Psychiatry and Psychotherapy, University of Greifswald and Hospital for Addictive Disorders, Stralsund General Hospital, Germany

Received 2 November 2001; first review notified 13 October 2002; accepted 29 October 2002

— Aims and Methods: Alcohol withdrawal treatment efficacy of tiapride/carbamazepine (A) vs clomethiazole (B) vs diazepam (C) in non-intoxicated patients and vs tiapride/carbamazepine in intoxicated patients (D; breath alcohol concentration >= 1 g/l) was tested (n = 127) in a controlled randomized open-label study. Results: Efficacy and safety were not different between groups (total group: delirium, 3.9%; seizure, 0.8%), except for a lack of efficacy in 18% of intoxicated tiapride/carbamazepine patients. A change of medication in this group was necessary only when primarily intoxicated patients had reached the non-intoxicated range. Conclusions: Treatment with tiapride/carbamazepine in alcohol-intoxicated patients proved to be safe.


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