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Alcohol and Alcoholism Vol. 37, No. 5, pp. 436-440, 2002
© 2002 Medical Council on Alcohol

SUCROSE SELF-ADMINISTRATION PREDICTS ONLY INITIAL PHASE OF ETHANOL-REINFORCED BEHAVIOUR IN WISTAR RATS

Artur Rogowski1, Wojciech Kostowski1,2 and Przemyslaw Bienkowski1,*

1 Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9 St., PL-02957 Warsaw and
2 Department of Experimental and Clinical Pharmacology, Medical University, Krakowskie Przedmiescie 26/28 St., PL-00527 Warsaw, Poland

Received 12 November 2001; first review notified 1 March 2002; accepted 14 March 2002

— Aims: To characterize the relationship between the sucrose- and ethanol-reinforced behaviour in Wistar rats. Methods: Subjects (n = 31) were trained to lever press for 8% (v/v) ethanol in an operant procedure where increasing concentrations of ethanol were introduced in the presence of 8% (w/v) sucrose. The sucrose concentration was subsequently decreased from 8 to 0%. Subjects were allowed to stabilize their intake of 8% ethanol over the next 20 days. Results: Self-administration of 8% sucrose (ml/kg) significantly correlated with ethanol consumption (g/kg) on days 1–5 of the 8% ethanol self-administration period. This relationship completely disappeared during the subsequent weeks of ethanol self-administration (days 6–20). Conclusions: The results of the present study, combined with our previous findings, may indicate that self-administration of sucrose predicts only the initial phase of ethanol-taking behaviour in Wistar rats.


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