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Alcohol and Alcoholism Vol. 37, No. 4, pp. 347-354, 2002
© 2002 Medical Council on Alcohol

CONTRIBUTION OF FRONTAL CEREBRAL BLOOD FLOW MEASURED BY 99mTc-BICISATE SPECT AND EXECUTIVE FUNCTION DEFICITS TO PREDICTING TREATMENT OUTCOME IN ALCOHOL-DEPENDENT PATIENTS

Xavier Noël,*, Rita Sferrazza, Martial Van der Linden,2, Jacques Paternot,1, Michel Verhas,1, Catherine Hanak,1, Isidore Pelc,1 and Paul Verbanck,1

Departments of Psychiatry and
1 Nuclear Medicine, Free University of Brussels, Brugmann Hospital, Belgium and
2 Department of Cognitive Psychopathology, University of Geneva, Geneva, Switzerland

Received 29 August 2001; in revised form 14 December 2001; accepted 21 January 2002

— Aim: To determine whether inhibition and working memory deficits, and reduced regional cerebral blood flow (rCBF) (previously shown to be related), measured at the end of a detoxification programme, predict alcoholic relapse 2 months later. Methods: Twenty uncomplicated alcoholic inpatients were investigated at the end of detoxification, at least 7 days since the last dose of diazepam, and a mean of 18.8 days since the last drink. Their performance was assessed on the inhibition (Hayling) test, working memory (Alpha-span task), episodic memory (California Verbal Learning Test) and abstract reasoning (Progressive Matrices). Frontal CBF was assessed at the same time with a semiquantitative 99mTc-Bicisate SPECT procedure. Patients were contacted 2 months later. Patients who abstained (n = 9) did not differ from those who relapsed (n = 11) on age, gender, smoking, duration of alcohol misuse, number of previous detoxifications, amount of ethanol consumed the month prior to admission to the detoxification programme, state anxiety, trait anxiety, or depression. Results: Relapsed subjects had shown a lower uptake of 99mTc-Bicisate in the bilateral medial frontal gyrus (n = 9; mean ratio ± SD = 0.69 ± 0.006) than abstainers (n = 11; 0.85 ± 0.19), and poorer performance on the Alpha-span task and the Hayling test. The other tests were not different. Conclusions: Inhibition and working memory deficits, associated with low levels of CBF in the medial frontal gyrus, are related to the difficulty of maintaining short-term abstinence from alcohol.


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