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Alcohol and Alcoholism Vol. 37, No. 3, pp. 229-235, 2002
© 2002 Medical Council on Alcohol

EFFECT OF CHRONIC ALCOHOL CONSUMPTION ON THE ETHANOL- AND ACETALDEHYDE-METABOLIZING SYSTEMS IN THE RAT GASTROINTESTINAL TRACT

Pavel Pronko,*, Lyubov Bardina, Valentina Satanovskaya, Antonina Kuzmich and Sergey Zimatkin1

Institute of Biochemistry, National Academy of Sciences of Belarus, Laboratory of Alcohol and Aldehyde Biochemistry, Grodno 230017, Belarus and
1 Grodno State Medical University, Grodno, 230015, Belarus

Received 11 May 2001; first review notified 20 November 2001; accepted 3 December 2001

The activities of alcohol dehydrogenase (ADH), catalase, microsomal ethanol-oxidizing system (MEOS) and aldehyde dehydrogenase (ALDH) were measured in gastric, small intestinal, colonic and rectal mucosal samples of rats fed on a liquid alcohol diet for 1 month. In the rectum and large intestine of control animals, the activities of ADH, MEOS and catalase were maximal, whereas the activity of ALDH was minimal. After chronic alcohol intoxication, MEOS activity increased significantly in the stomach. An activation of catalase and MEOS and a decrease of the low-KM ALDH activity were observed in the rectum of experimental animals. In rats consuming the alcohol diet, hypertrophy of crypts and an increased number of mitoses were noticed in colonic and rectal mucosa. Acute alcohol intoxication (2 g/kg, intragastrically) produced significantly higher acetaldehyde concentrations in the contents of the large intestine and rectum of rats receiving alcohol chronically compared to controls. Thus, after chronic alcohol intoxication, the large intestine regions showed a greater imbalance between the activities of acetaldehyde-producing and -oxidizing enzymes, which resulted in accumulation of acetaldehyde. This mechanism can account for the local toxicity of ethanol after its chronic consumption, and relates the development of mucosal damage and compensatory hyper-regenerative processes, and possibly carcinogenesis, in the colonic and rectal mucosae of alcoholics to the effects of acetaldehyde.


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