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Alcohol and Alcoholism Vol. 37, No. 1, pp. 87-92, 2002
© 2002 Medical Council on Alcohol

MODERATE ALCOHOL INTAKE IN PREGNANCY AND THE RISK OF SPONTANEOUS ABORTION

Ulrik Kesmodel1,3,*, Kirsten Wisborg1,2, Sjúrdur Fródi Olsen4, Tine Brink Henriksen1,2 and Niels Jørgen Secher1,5

1 Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology,
2 Department of Paediatrics, Aarhus University Hospital, Skejby Sygehus, 8200 Aarhus N,
3 Department of Epidemiology and Social Medicine, University of Aarhus, Vennelyst Boulevard 6, 8000 Aarhus C,
4 Maternal Nutrition Group, Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark and
5 Department of Obstetrics and Gynaecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia

Received 4 May 2001; first review notified 9 July 2001; accepted 7 August 2001

— Women attending routine antenatal care at Aarhus University Hospital, Denmark, from 1989 to 1996 were eligible for this cohort study on the association between alcohol intake in pregnancy and the risk of spontaneous abortion. We included 24 679 singleton pregnancies in the study. We used Cox regression analyses with delayed entry for the analyses. We found an increased risk of spontaneous abortion in the first trimester (7–11 completed weeks of gestation) for women consuming >=5 drinks/week. We found no association between alcohol intake and spontaneous abortion during the second trimester. Common methodological problems in relation to studies on spontaneous abortions are discussed, as are problems with possible under-reporting of alcohol consumption. We conclude that women consuming >=5 drinks/week are at increased risk of first trimester spontaneous abortion.


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