Alcohol and Alcoholism Vol. 37, No. 1, pp. 67-73, 2002
© 2002 Medical Council on Alcohol
DOUBLE-BLIND CONTROLLED TRIAL OF 
-HYDROXYBUTYRATE AND CLOMETHIAZOLE IN THE TREATMENT OF ALCOHOL WITHDRAWAL
Anton-Proksch-Institute, Vienna and
1 Department of Psychiatry, University Clinic, Vienna, Austria
Received 24 July 2000; first review notified 25 May 2001; accepted 19 July 2001
— The aim of this double-blind, comparative study was to assess the efficacy and safety of 
-hydroxybutyrate (GHB) in ameliorating the symptoms of alcohol withdrawal. Newly admitted alcohol-dependent patients (n = 98) were randomized to receive either clomethiazole 1000 mg daily (CLO group) (n = 33), or 50 mg GHB/kg body wt (n = 33) or 100 mg GHB/kg body wt (n = 32). This dose was administered for 5 days, halved on day 6, and on days 7 and 8 only placebo was given. As CLO is available as capsules and GHB as syrup, a double-dummy method was used to try to ensure blindness. The groups were matched in terms of baseline demographic and alcohol-related variables. There was no difference between the three treatments in ratings of alcohol withdrawal symptoms nor requests for additional medication. After tapering off the active medication, there was no increase in withdrawal symptoms, indicating that physical tolerance did not develop to either GHB or CLO within the 5-day treatment period. The most frequently reported side-effect of GHB was transient vertigo, particularly after the evening double dose.
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