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Alcohol and Alcoholism Vol. 37, No. 1, pp. 49-51, 2002
© 2002 Medical Council on Alcohol

ALCOHOL-INDUCED ALTERATIONS IN BLOOD AND ERYTHROCYTE MEMBRANE IN DIABETICS

M. Paramahamsa, S. Aparna and N. Varadacharyulu,*

Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, A. P., India

Received 4 August 2000; first review notified 5 June 2001; accepted 5 July 2001

— Three groups consisting of 12 volunteers each, of alcoholic type 2 diabetics (non-insulin-dependent diabetes mellitus, NIDDM), non-alcoholic type 2 diabetics (NIDDM) and controls (teetotallers) were selected for assessing changes in lipids of plasma and erythrocyte membranes. Significant changes in cholesterol and phospholipids were observed in alcoholic diabetics suggesting a regulatory compensatory mechanism to resist the fluidizing action of ethanol as well as rigidification of erythrocyte membrane. A significant increase in lipid peroxidation of erythrocytes was observed, indicating the damage associated with disrupted organization, structure and function of membranes in alcoholic diabetics.


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