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Alcohol and Alcoholism Vol. 37, No. 1, pp. 25-29, 2002
© 2002 Medical Council on Alcohol

BILE SALTS MODULATE CHRONIC ETHANOL-INDUCED HEPATOTOXICITY

Anne-Marie Montet, Laurence Oliva, Françoise Beaugé1 and Jean-Claude Montet,*

Laboratoire de Physiopathologie Hépatique, INSERM, 46 Boulevard de la Gaye, 13009, Marseille and
1 Centre de Recherche Pernod-Ricard, Créteil, France

Received 2 March 2001; first review notified 28 July 2001; accepted 6 August 2001

— This study tested the hypothesis that chronic ethanol-induced injury in rats may be modified by the hydrophobicity of the bile acid pool. The supplementation to chronic ethanol feeding (28 days) with chenodeoxycholate, a hydrophobic bile salt, aggravated steatosis (accumulation of triacylglycerols and cholesterol esters), lipoperoxidation and cytolysis (expressed as elevations of activities of aspartate aminotransferase and glutamate dehydrogenase), while the addition of ursodeoxycholic acid, a hydrophilic bile salt, alleviated ethanol-induced hepatic alterations. Furthermore, our data show that ursodeoxycholic acid still exerts its beneficial effects in a model of more severe hepatic intoxication induced by the co-administration of ethanol and chenodeoxycholic acid. The hepato-protective effect observed appears to be independent of the choleretic properties of ursodeoxycholic acid and may be due partly to the capacity of the bile acid to preserve mitochondria.


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