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Alcohol and Alcoholism Vol. 36, No. 4, pp. 323-328, 2001
© 2001 Medical Council on Alcoholism

Altered frontal lobe function suggested by source analysis of event-related potentials in impulsive violent alcoholics

Ina M. Tarkka*,, Jari Karhu1,, Jyrki Kuikka2,, Ari Pääkkönen1,, Kim Bergström2,, Juhani Partanen1, and Jari Tiihonen3,

Department of Neurology and Brain Research and Rehabilitation Center Neuron, Department of
1 Clinical Neurophysiology,
2 Departments of Neurology and Clinical Physiology, Kuopio University Hospital, University of Kuopio and
3 Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland

Received 17 October 2000; first review notified 8 January 2001; accepted 31 January 2001

Scalp-recorded event-related potentials (ERPs) are sensitive indicators of subtle alterations in cerebral processes. We assessed automatic auditory adaptation and detection of novel stimuli in violent and non-violent alcoholics and normal subjects. Source analysis of ERPs revealed active medial temporal and frontal regions in all subjects. Frontal lobe processed alerting tones in violent alcoholics, whereas non-violent alcoholics and normal subjects processed them in medial temporal brain areas. Detection of deviant tones appeared simultaneously in frontal and temporal areas in violent alcoholics, but sequentially in other groups. These findings imply alterations in arousal and involuntary adaptive processes in cortical networks associated with violent behaviour and alcoholism.


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