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Alcohol and Alcoholism Vol. 36, No. 4, pp. 318-322, 2001
© 2001 Medical Council on Alcoholism

Alcohol preference: association with reduced striatal nicotinic receptors

Yousef Tizabi*,, Bruk Getachew, Martha Davila-Garcia and Robert E. Taylor

Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA

Received 14 January 2000; first review notified 14 February 2001; accepted 24 February 2001

This study was designed to determine whether inherent alcohol preference is associated with differential expression of central nicotinic receptors. [3H]Cytisine and [125I]{alpha}-bungarotoxin binding-site, ligands selective for {alpha}4ß2 and {alpha}7 nicotinic receptor subtypes, respectively, were determined in various brain regions of alcohol-preferring (P) and non-preferring (NP) rats. Only the striatum of P rats had a reduction in the number of binding sites for both ligands, compared to NP rats. The data suggest a link between striatal nicotinic receptors and alcohol preference.


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