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Alcohol and Alcoholism Vol. 36, No. 4, pp. 309-313, 2001
© 2001 Medical Council on Alcoholism

Changes in ethanol preference by rats treated with {gamma}1 and {gamma}2 GABAA receptor subunit antisense oligodeoxynucleotides

Ewa Malatynska1,2,*,, Wanda Dyr3,, Pawel Krzascik3,4, and Wojciech Kostowski3,4,

Indiana University School of Medicine,
1 Departments of Pharmacology & Toxicology and
2 Psychiatry, Evansville, IN 47712, USA,
3 Institute of Psychiatry and Neurology, Department of Pharmacology and Physiology of the Nervous System, 02957 Warsaw and
4 Medical Academy, Department of Experimental and Clinical Pharmacology, 00-927 Warsaw, Poland

Received 12 October 2000; first review notified 22 January 2001; accepted 5 February 2001

Micro-injections (10 nmol/day over 5 days) of antisense oligodeoxynucleotides (aODNs) to {gamma}-aminobutyric acid A (GABAA) receptor {alpha}1 and {gamma}2 subunits reduce the mRNA for these subunits in rat brain. In this study, the effects of {alpha}1 and {gamma}2 subunit aODNs on rat alcohol preference were investigated. Reduction of the {alpha}1 subunit mRNA decreased, whereas reduction of the {gamma}2 subunit mRNA increased, ethanol intake in rats.


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