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Alcohol and Alcoholism Vol. 36, No. 3, pp. 266-270, 2001
© 2001 Medical Council on Alcoholism

Diagnostic usefulness of carbohydrate-deficient transferrin for detecting alcohol-related problems in hospitalized patients

A. Gómez*,, A. Conde1,, J. A. Aguiar, J. M. Santana, A. Jorrín and P. Betancor1,

Family Practice, San Gregorio Health Care Centre and
1 Internal Medicine, Doctor Negrín General Hospital, Las Palmas, Spain

Received 24 March 2000; in revised form 23 August 2000; accepted 29 December 2000

We evaluated the diagnostic usefulness of carbohydrate-deficient transferrin (CDT) for detecting alcohol-related problems (ARP) in hospitalized patients, assessed potential differences according to gender and age, and compared this value to the other screening measures conventionally used, namely the CAGE questionnaire and standard biological markers MCV (mean corpuscular volume) and GGT ({gamma}-glutamyltransferase). CDT sensitivity for detecting ARP was 70%, specificity 75% and area under the receiver operating characteristic curve 0.76%. Its sensitivity was shown to be lower both in the female group (65 vs 71%) as well as in the younger-age group whereas its specificity was lower in the liver-damaged group (55%). CDT diagnostic value did not exceed that of CAGE (sensitivity 78% and specificity 99%), MCV (sensitivity and specificity 74%) or GGT (sensitivity 82% and specificity 53%) but was better than those of other biochemical measures. We conclude that CDT is an effective biological marker for the detection of ARP among hospitalized patients, but that its diagnostic usefulness does not exceed that of some other alternative measures commonly used.


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Home page
 J Am Board Fam MedHome page
M. Fleming and M. Mundt
Carbohydrate-Deficient Transferrin: Validity of a New Alcohol Biomarker in a Sample of Patients with Diabetes and Hypertension
J Am Board Fam Med, July 1, 2004; 17(4): 247 - 255.
[Abstract] [Full Text] [PDF]


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