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Alcohol and Alcoholism Vol. 35, No. 6, pp. 594-600, 2000
© 2000 Medical Council on Alcoholism

EFFECTS OF ALCOHOL AND THE EVENING MEAL ON SHEAR-INDUCED PLATELET AGGREGATION AND URINARY EXCRETION OF PROSTANOIDS

Heikki Numminen, Michiko Kobayashi1, Shinichiro Uchiyama1, Makoto Iwata1, Yasuo Ikeda2, Asko Riutta3, Martti Syrjälä4, Riitta Kekomäki5 and Matti Hillbom*

Department of Neurology, Oulu University Hospital, Oulu, Finland,
1 Department of Neurology, Tokyo Women's Medical College, Tokyo, Japan,
2 Department of Internal Medicine, Keio University, Tokyo, Japan,
3 Department of Pharmacological Sciences, University of Tampere, Tampere,
4 Department of Clinical Chemistry, Helsinki University Hospital, Helsinki and
5 Finnish Red Cross Blood Transfusion Service, Helsinki, Finland

Received 29 December 1999; in revised form 15 May 2000; accepted 8 June 2000

Moderate regular alcohol intake has been found to be associated with a decreased risk for coronary heart disease and stroke. We investigated the effects of acute intake of red wine (60 g ethanol) and a standard dinner under controlled conditions on haemostatic factors. Shear-induced platelet aggregation (SIPA) decreased after the intake of alcohol irrespective of whether the subjects were fasting or not, and also after the intake of food. The intake of alcohol inhibited the postprandial increase of von Willebrand factor multimers. Plasma levels of plasminogen activator inhibitor 1 activity (PAI-1) and serum triglycerides were increased by alcohol. Excretion of the platelet thromboxane A2 metabolites 11-dehydrothromboxane B2 and 2,3-dinorthromboxane B2, as well as the endothelial prostacyclin metabolite 2,3-dinor-6-ketoprostaglandin F1{alpha}, into urine was not influenced by either alcohol or food. We conclude that eating a dinner together with red wine has no untoward effect on SIPA and that the decrease of SIPA is not specific for alcohol.


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