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Alcohol and Alcoholism Vol. 35, No. 3, pp. 249-254, 2000
© 2000 Medical Council on Alcoholism

ADENYLYL CYCLASE ACTIVITY IS INCREASED IN YOUNGER, BUT DECREASED IN OLDER, ALCOHOLIC PATIENTS AFTER DETOXIFICATION

NORBERT DAHMEN, THORSTEN PAULY, ARMIN SZEGEDI, HERMANN WETZEL, ION ANGHELESCU, KIRSTEN FERDINAND and CHRISTOPH HIEMKE*

Department of Psychiatry, University of Mainz, Untere Zahlbacher Straße 8, 55131 Mainz, Germany

Received 6 July 1999; first review notified 11 October 1999; accepted 7 November 1999

Acute and chronic administration of ethanol leads to alterations of the adenylyl cyclase (AC) signal transduction pathway. This study examined whether the formation of cAMP by AC in lymphocytes correlates with age in alcoholic patients and in healthy controls. Blood was drawn for preparation of lymphocyte membranes and for determination of basal, GTP{gamma}S-stimulated, and forskolin-stimulated AC activity from 68 actively drinking alcoholic patients (age, mean ± SD: 45 ± 10; range: 26–69 years) after ethanol detoxification. The patients' AC activity correlated negatively with age. In contrast, no effect of age was observed in the healthy controls (age, mean ± SD: 42 ± 11; range: 24–65 years). The age-related decrease in AC activity of alcoholic patients could not be attributed to the duration of regular alcohol intake. It was partly due to the large variance of AC activity in younger and middle-aged alcoholics.


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