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Alcohol and Alcoholism Vol. 35, No. 1, pp. 55-59, 2000
© 2000 Medical Council on Alcoholism

APPLICATION OF CROSS-IMPACT ANALYSIS TO THE RELATIONSHIP BETWEEN ALDEHYDE DEHYDROGENASE 2 ALLELE AND THE FLUSHING SYNDROME

Guang Wu*

Department of Medico-Biocybernetics, Faculty of Medico-Biology, Russian State Medical University, Moscow 117437, Russia

Received 30 December 1998; accepted 18 May 1999

The experimental approach has been used to study successfully the relationship between the polymorphism of aldehyde dehydrogenase 2 and the flushing syndrome. In the present study, a probabilistic approach was used to analyse this relationship. Using cross-impact analysis and experimental data, the probability of the occurrence of flushing, the extent by which ALDH2*2/*2 enhances flushing more than ALDH2*1/*2, the extent by which ALDH2*1/*1 enhances non-flushing more than ALDH2*1/*2, etc. can be calculated. Two examples are given to show the potential use of cross-impact analysis.


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