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Alcohol and Alcoholism Vol. 34, No. 5, pp. 718-725, 1999
© 1999 Medical Council on Alcoholism

MENTAL WELL-BEING IN ALCOHOL WITHDRAWAL: RELATIONSHIP TO {alpha}2-ADRENOCEPTOR FUNCTION

Claudia Fahlke*, Ulf Berggren1 and Jan Balldin1

Department of Psychology, PO Box 500, SE-405 30 Göteborg and
1 Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Unit for Research on Alcoholism and Substance Abuse, Sahlgrenska University Hospital/Mölndal, SE-431 80 Mölndal, Göteborg University, Sweden

Received 5 October 1998; first review notified 16 December 1998; accepted 23 February 1999

The possible relationship between postsynaptic {alpha}2-adrenoceptor function, as assessed by the growth hormone (GH) response to clonidine (CLON) and aspects of mental well-being by self-report of mood using the Swedish Mood Adjective Check List, was investigated in alcohol-dependent patients in the early withdrawal period. Patients had blunted GH responses to CLON and worse mental well-being than control subjects immediately after the end of alcohol intake. No relation was found between mental well-being and postsynaptic {alpha}2-adrenoceptor function. After 1 week, the GH responses to CLON remained blunted, whereas the state of mental well-being had improved to levels similar to those of control subjects. The results further support a downregulated {alpha}2-adrenoceptor function during 1 week of alcohol withdrawal. Furthermore, even if subsensitive postsynaptic {alpha}2-adrenoceptor function was not generally related to state of mood, patients with the lowest postsynaptic {alpha}2-adrenoceptor function reported the highest levels in the dimensions pleasantness/unpleasantness and activation/deactivation when sober.


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