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Alcohol and Alcoholism Vol. 34, No. 5, pp. 685-689, 1999
© 1999 Medical Council on Alcoholism

Rapid Communication

OPERANT RESPONDING FOR ETHANOL IN RATS WITH A LONG-TERM HISTORY OF FREE-CHOICE ETHANOL DRINKING

Eliza Koros1, Wojciech Kostowski1,2 and Przemyslaw Bienkowski1,3,*

1 Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Al. Sobieskiego 1/9, PL-02957 Warsaw,
2 Department of Experimental and Clinical Pharmacology, Warsaw Medical University, ul. Krakowskie Przedmiescie 26/28, PL-00527, Warsaw and
3 Clinical Psychopharmacology Laboratory, National Centre of Sport Medicine, ul. Wawelska 5, PL-02034 Warsaw, Poland

Received 17 March 1999; first review notified 7 June 1999; accepted 21 June 1999

Wistar rats were allowed to drink ethanol in a two-bottle (water vs 2–8% v/v ethanol) and then in a three-bottle choice paradigm (water vs 8% ethanol vs 16% ethanol, v/v). After 7 months of free access to alcohol, the subjects were trained to respond for 8% ethanol in an operant procedure. No relationship was found between prior alcohol drinking and lever pressing for ethanol.


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