Alcohol and Alcoholism Vol. 34, No. 4, pp. 506-510, 1999
© 1999 Medical Council on Alcoholism
Rapid Communication
THE SYNERGISTIC ACTION OF ETHANOL AND NERVE GROWTH FACTOR IN THE INDUCTION OF NEURONAL NITRIC OXIDE SYNTHASE
Department of Pediatrics, University of California at San Francisco, San Francisco, CA 94143-0106, USA
Received 26 January 1999; accepted 16 March 1999
Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
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