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Alcohol and Alcoholism Vol. 34, No. 3, pp. 283-288, 1999
© 1999 Medical Council on Alcoholism

Rapid Communication

DIZOCILPINE (MK-801) PREVENTS THE DEVELOPMENT OF SENSITIZATION TO ETHANOL IN DBA/2J MICE

Julie Broadbent* and Adam Z. Weitemier

Department of Behavioral Neuroscience and the Portland Alcohol Research Center, Oregon Health Sciences University, Portland, OR 97201-3098, USA

Received 16 November 1998; first review notified 18 January 1999; accepted 12 February 1999

DBA/2J mice repeatedly exposed to ethanol (2 g/kg, i.p. every 48 h for 8 days) exhibit sensitization to the locomotor stimulant effects of ethanol. Pretreatment with the NMDA receptor antagonist dizocilpine (0.2–0.3 mg/kg, i.p.) completely prevents the development of sensitization. Thus, NMDA receptors appear to play an important role in behavioural sensitization to ethanol.


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