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© 1998 Medical Council on Alcohol

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BENFOTIAMINE IN TREATMENT OF ALCOHOLIC POLYNEUROPATHY: AN 8-WEEK RANDOMIZED CONTROLLED STUDY (BAP I STUDY)

H. WOELK*, S. LEHRL1, R. BITSCH2 and W. KÖPCKE3

Psychiatrisches Krankenhaus Psychiatrisches Krankenhaus. Licher Str. 106, 35394 Giessen
1Kopfklinikum. Abteilung für medizinische Psychologie und Psychopathometrie Schwabachanlage 6. 91054 Erlangen
2Friedrich Schiller Universität, Institut für Ernährung und Umwelt Dornburger Str. 24-29. 07743 Jena
3Westfälische Wilhelms-Universitat. Institut für medizinische Informatik Domagkstr. 9, 48149 Münster, Germany

*Author to whom correspondence and reprint requests should be addressed

Received 24 October 1997; accepted 27 April 1998

A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy. BAP I). The study period was 8 weeks and 84 patients fulfilled all the prerequisite criteria and completed the study as planned. Benfotiamine led to significant improvement of alcoholic polyneuropathy. Vibration perception (measured at the tip of the great toe) significantly improved in the course of the study, as did motor function, and the overall score reflecting the entire range of symptoms of alcoholic polyneuropathy. A tendency toward improvement was evident for pain and co-ordination, no therapy-specific adverse effects were seen.


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