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© 1996 Medical Council on Alcohol

research-article

CIRCADIAN DRINKING PATTERN OF SARDINIAN ALCOHOL-PREFERRING RATS

ROBERTA AGABIO, GIAMPIERO CORTIS1, FABIO FADDA2, GIAN LUIGI GESSA, CARLA LOBINA3, ROBERTA REALI and GIANCARLO COLOMBO*,3

‘Bernard B. Brodie’ Department of Neuroscience, University of Cagliari Via Porcell 4, 1-09124 Cagliari
1‘Bernard B. Brodie’ Department of Neuroscience, Institutes of Forensic Medicine, University of Cagliari Via Porcell 4, 1-09124 Cagliari
2‘Bernard B. Brodie’ Department of Neuroscience, Institutes of Human Physiology, University of Cagliari Via Porcell 4, 1-09124 Cagliari
3C.N.R. Centre for Neuropharmacology Via Porcell 4, 1-09124 Cagliari, Italy

*Author to whom correspondence should be addressed

Received 27 September 1995; first review notified 30 January 1996; accepted 15 February 1996

The present study was designed to assess the temporal pattern of ethanol intake over a 24 h period in selectively bred, Sardinian alcohol-preferring (sP) rats Ethanol intake occurred under the two-bottle, free choice regimen. sP rats consumed ethanol in three distinct peaks, rather regularly distributed over the 12 h dark phase of the light-dark cycle and positively correlated with food intake episodes. The temporal distribution of ethanol intake and estimated blood alcohol levels are consistent with the hypothesis that sP rats voluntarily drink ethanol for its pharmacological effects


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