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© 1993 Medical Council on Alcohol

research-article

REDUCED [3H]SCH 23390 BINDING AND DA-SENSITIVE ADENYLYL CYCLASE IN THE LIMBIC SYSTEM OF ETHANOL-PREFERRING RATS

MARIA GRAZIELLA DE MONTIS*, CARLA GAMBARANA*, GIAN LUIGI GESSA{dagger}, DOMENICO MELONI*, ALESSANDRO TAGLIAMONTE* and ENNIO STEFANINI{dagger}

*Institute of Pharmacology, University of Siena Via delle Scotte 6, 53100 Siena, Italy
{dagger}Department of Neuroscience. University of Cagliari Via Porcell 4,09124 Cagliari, Italy

Received 10 September 1992; first review notified 4 December 1992; accepted 30 January 1993

Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) to dopamine stimulation were studied in the limbic areas and the caudate-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non-preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [3H]SCH 23390 binding, and a decreased response to DA stimulation than SNP and UW animals. Since SP rats have also a low number of D2 receptors, the results suggest that an altered dopaminergic transmission may underlie their innate alcohol preference


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[Abstract] [Full Text]


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