Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by ROSSETTI, Z.
Right arrow Articles by GESSA, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ROSSETTI, Z.
Right arrow Articles by GESSA, G. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Medical Council on Alcohol

research-article

RAPID COMMUNICATION: BIPHASIC EFFECT OF ETHANOL ON NORADRENALINE RELEASE IN THE FRONTAL CORTEX OF AWAKE RATS

ZVANIL ROSSETTI*, GIORGIO LONGU{dagger}, GIUSEPPE MERCURO{dagger}, YOUSEF HMAIDAN* and GIAN LUIGI GESSA*

*B. B. Brodie Department of Neuroscience via Porcell 4, 09124 Cagliari
{dagger}Institute of Cardiology, University of Cagliari 09124 Cagliari, Italy

Received 20 March 1992; accepted 18 August 1992

Ethanol elicited a biphasic effects on the extracellular noradrenaline (NA) concentrations in the rat frontal cortex, as assessed by microdialysis in awake animals. A low dose of ethanol (0.2 g/kg i.p.) raised NA output to about 160% of baseline levels. In contrast, a dose of 2 g/kg inhibited NA output to about 70% of pre-drug levels. These results suggest that the decrease in cortical NA output may reflect the sedative-hypnotic properties of ethanol at high doses, whereas the stimulation of extraneuronal NA may represnt a biochemical correlate of the arousal and increased alertness elicited by low doses of ethanol.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.