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© 1987 Medical Council on Alcohol

research-article

CLONIDINE IN ALCOHOL WITHDRAWAL: A PILOT STUDY OF DIFFERENTIAL SYMPTOM RESPONSES FOLLOWING I.V. CLONIDINE

PAUL GLUE and DAVID NUIT*,

University Department of Psychiatry Warneford Hospital, Oxford, U.K.

Correspondence to: Dr D. J. Nutt, Chief. Section of Clinical Science. Laboratory of Clinical Studies. National Institute on Alcohol Abuse and Alcoholism. Building 10/3819, 9000 Rockville Pike, Bethesda, MD 20892, U.S.A.

Received 16 October 1986; accepted 5 December 1986

The effects of an i.v. bolus of clonidine (1.5 mg/kg) on withdrawal symptoms were studied in 7 male alcoholics, and compared with 7 normal controls. Clonidine reduced both subjective and objective measures of withdrawal but this only reached significance for scores of depression and muscle tension. In comparison with controls alcoholics in withdrawal showed reduced sedative effects of clonidine.


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P. Glue, D. Nutt, and P. Glue
Clonidine challenge testing of alpha-2-adrenoceptor function in man: the effects of mental illness and psychotropic medication
J Psychopharmacol, January 1, 1988; 2(3-4): 119 - 137.
[Abstract] [PDF]


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