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Alcohol and Alcoholism Advance Access originally published online on July 20, 2008
Alcohol and Alcoholism 2008 43(5):564-568; doi:10.1093/alcalc/agn057
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© The Author 2008. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved

Circadian Phenotype in Patients with the Co-Morbid Alcohol Use and Bipolar Disorders

Taina Hätönen1,2,3, Sebastian Forsblom1,{dagger}, Tuula Kieseppä1,3, Jouko Lönnqvist1,3 and Timo Partonen1,*

1 Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
2 Finnish Student Health Service, Helsinki, Finland
3 Department of Psychiatry, University of Helsinki, Helsinki, Finland

* Corresponding author: Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI-00300 Helsinki, Finland Tel: +358-9-47448660; Fax: +358-9-47448478; E-mail: timo.partonen{at}ktl.fi

Received 24 November 2006; first review notified 26 February 2007; in revised form 17 March 2008; accepted 19 June 2008


  Abstract

Aims: Alcohol misuse is associated with bipolar disorder. Abnormalities in the circadian clockwork play a role in the pathogenesis of bipolar disorder. Alcohol intake is likely to affect the circadian phenotype. We aimed at analysing the behavioural trait of the preference to morning or evening hours for the daily activities in bipolar disorder patients with or without the co-morbid alcohol use. Methods: Our nationwide sample of families included patients with bipolar disorder born during 1940–1969 having at least one hospitalization due to bipolar disorder during 1969–1991 and their first-degree relatives. All the 148 participants were interviewed using the Structured Clinical Interview for DSM-IV Axis I Disorders and assessed using the Morningness–Eveningness Questionnaire whose factor matrix applying for the maximum likelihood principle was calculated for the first time. Results: Patients with the co-morbid alcohol use disorder were more of the morning type as compared with patients with bipolar disorder only. Conclusions: Co-morbid patients preferred more the morning hours for their daily activities, indicative of alcohol consumption having an effect on the circadian clock.

{dagger} Contributed equally to this work.


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