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Alcohol and Alcoholism Advance Access originally published online on April 12, 2008
Alcohol and Alcoholism 2008 43(4):423-430; doi:10.1093/alcalc/agn021
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© The Author 2008. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved

Neuropsychological Function and Platelet Monoamine Oxidase Activity Levels in Type I Alcoholic Patients

Samuel Pombo1,2*, Pilar Levy2, Manuel Bicho2, Fátima Ismail1 and J M Neves Cardoso1

1 Alcoholism Unit of the Psychiatric Service of Santa Maria General Hospital, Núcleo de Estudos e Tratamento do Etilo-Risco (NETER), Lisbon, Portugal
2 Genetic Laboratory, Medical School University of Lisbon, Lisbon, Portugal

* Author to whom correspondence should be addressed at: Núcleo de Estudos e Tratamento do Etilo-Risco (NETER), Serviço de Psiquiatria do Hospital de Santa Maria, Avenue Prof. Egas Moniz, 1649-028 Lisboa, Portugal. E-mail: samuelpombo{at}gmail.com

Received 30 July 2007; first review notified 15 November 2007; in revised form 17 December 2007; accepted 29 February 2008


  Abstract

Aims: To explore neuropsychological function in two differentiated patterns of platelet monoamine oxidase B (MAO B) activity in alcoholic patients. Methods: Neuropsychological examination and platelet MAO B activity extracted from blood were collected from 42 alcohol-dependent patients recruited in the alcoholism unit (NETER) of the Psychiatric Service of Santa Maria University Hospital. Results: Alcoholics presented significantly low levels of platelet MAO B activity, when compared with control subjects; platelet MAO B activity in alcoholics classified as "under average subgroup" showed significant lower scores in the Raven Progressive Matrix and higher scores in hostility dimension, when compared with platelet MAO B activity in "above average subgroup." Conclusions: Results suggested platelet MAO B as a trait marker also to type I alcohol-dependent patients and the two observed associations between platelet MAO B activity with neurocognitive measures of executive functions (nonverbal reasoning) and psychopathological dimension such as hostility may support the notion about the effect of platelet MAO B activity in the further development of an impulsive cognitive style.


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