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Alcohol and Alcoholism Advance Access originally published online on August 21, 2007
Alcohol and Alcoholism 2007 42(6):509-512; doi:10.1093/alcalc/agm068
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Copyright © The Author 2007. Published by Oxford University Press on behalf of the Medical Council on Alcohol.

Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence

Stefan Bleich{dagger},*, Dominikus Bönsch{dagger}, Johannes Rauh, Kristina Bayerlein, Roland Fiszer, Helge Frieling and Thomas Hillemacher

Department of Psychiatry and Psychotherapy; University of Erlangen-Nuremberg, Germany

* Author to whom correspondence should be addressed at: Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany. Tel: (+49) 9131 8 533001; Fax: (+49) 9131 8534105; E-mail: stefan.bleich{at}uk-erlangen.de

Received 1 April 2007; first review notified 7 June 2007; in revised form 17 July 2007; accepted 27 July 2007


  Abstract

Aims: Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism. Method: The present study investigated an association of this polymorphism with obsessive-compulsive alcohol craving in 124 male patients admitted for alcohol detoxification treatment. Results: We found significantly higher compulsive craving in patients with the long allele of the 5-HTTLPR polymorphism [at admission: analysis of variance (ANOVA): F = 3.48, P = 0.034, general linear model: F = 3.92, P = 0.023; after 7 days: ANOVA: F = 3.12, P = 0.049]. Conclusions: Our results suggest that the long variant of the 5-HTTLPR polymorphism is associated with higher compulsive alcohol craving at the beginning of alcohol withdrawal.

{dagger} S.B. and D.B. contributed equally to this work.


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