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Alcohol and Alcoholism Advance Access originally published online on April 19, 2006
Alcohol and Alcoholism 2006 41(4):368-371; doi:10.1093/alcalc/agl028
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© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved

ALDH2 PROMOTER POLYMORPHISM HAS NO EFFECT ON THE RISK FOR ALCOHOLISM

MITSURU KIMURA1, SHIGEKO KIMURA1, SACHIO MATSUSHITA1, HARUO KASHIMA2 and SUSUMU HIGUCHI1,*

1 National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan and 2 Department of Neuropsychiatry, School of Medicine, Keio University, Shinjuku, Tokyo, Japan

* Author to whom correspondence should be addressed at: National Hospital Organization, Kurihama Alcoholism Center, 5-3-1 Nobi, Yokosuka, Kanagawa 2390841, Japan. Tel.: +81 46 848 1550; Fax: +81 46 849 7743; E-mail: shiguchi{at}wa2.so-net.ne.jp

(Received 17 October 2005; first review notified 14 December 2005; in revised form 21 March 2006; accepted 22 March 2006)

Aim: To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism. Methods: Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed. Results: There were no significant differences between the genotype and allele frequencies of the –357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms. Conclusion: These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.


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