Skip Navigation


Alcohol and Alcoholism Advance Access originally published online on April 19, 2006
Alcohol and Alcoholism 2006 41(4):368-371; doi:10.1093/alcalc/agl028
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
41/4/368    most recent
agl028v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by KIMURA, M.
Right arrow Articles by HIGUCHI, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KIMURA, M.
Right arrow Articles by HIGUCHI, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author 2006. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved

ALDH2 PROMOTER POLYMORPHISM HAS NO EFFECT ON THE RISK FOR ALCOHOLISM

MITSURU KIMURA1, SHIGEKO KIMURA1, SACHIO MATSUSHITA1, HARUO KASHIMA2 and SUSUMU HIGUCHI1,*

1 National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan and 2 Department of Neuropsychiatry, School of Medicine, Keio University, Shinjuku, Tokyo, Japan

* Author to whom correspondence should be addressed at: National Hospital Organization, Kurihama Alcoholism Center, 5-3-1 Nobi, Yokosuka, Kanagawa 2390841, Japan. Tel.: +81 46 848 1550; Fax: +81 46 849 7743; E-mail: shiguchi{at}wa2.so-net.ne.jp

(Received 17 October 2005; first review notified 14 December 2005; in revised form 21 March 2006; accepted 22 March 2006)

Aim: To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism. Methods: Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed. Results: There were no significant differences between the genotype and allele frequencies of the –357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms. Conclusion: These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.