Skip Navigation


Alcohol and Alcoholism Advance Access originally published online on October 20, 2005
Alcohol and Alcoholism 2006 41(1):14-17; doi:10.1093/alcalc/agh225
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
41/1/14    most recent
agh225v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by CICHOZ-LACH, H.
Right arrow Articles by WOJCIEROWSKI, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CICHOZ-LACH, H.
Right arrow Articles by WOJCIEROWSKI, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author 2005. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved

GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS

HALINA CICHOZ-LACH1,*, JADWIGA PARTYCKA1, IRINA NESINA2, KRZYSZTOF CELINSKI1, MARIA SLOMKA1 and JACEK WOJCIEROWSKI2

1 Department of Gastroenterology and 2 Department of Medical Genetics, Medical University of Lublin, ul. Jaczewskiego 8, Lublin, Poland

* Author to whom correspondence should be addressed at: Tel.: +48 81 7430736; Fax: +48 81 7400068; E-mail: Lach.Halina{at}wp.pl

(Received 14 July 2005; first review notified 7 September 2005; accepted in revised form 29 September 2005)

Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR–restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in alcohol abusers compared with non-drinkers. The examinations of the group of alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of alcohol dependence between genders in the Polish population.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.